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    1. Common Short‑Term Adverse Events

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    Water Retention (Edema): Some users experience transient fluid accumulation in extremities or the face. This is typically mild and subsides after cessation of therapy.

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    4. Long‑Term Safety Considerations

    While the acute safety profile of ipamorelin is relatively benign, long‑term effects remain under‑investigated:

    Joint and Cartilage Health: Chronic stimulation of growth hormone pathways could influence cartilage metabolism. Some animal studies suggest potential for accelerated joint degeneration with prolonged exposure.

    Cardiovascular Impact: Growth hormone excess has been linked to hypertension and left ventricular hypertrophy in other contexts; whether ipamorelin induces comparable changes requires further longitudinal research.

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    Allergic Responses: Anaphylactic reactions are extremely rare but possible, especially in individuals with a history of peptide allergies.

    Neuropsychiatric Symptoms: A few case reports mention mood swings or anxiety during the initial weeks of therapy; these are typically self‑limited.

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    Overall Tolerability – Most users tolerate ipamorelin well, experiencing only mild injection site discomfort and temporary fluid retention.

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